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hc; I always believed that Donnie held a lot of guilt after Leo was hurt so badly he slipped into a coma. Berating himself constantly that if he had simply listened Leo would be okay, not even able to go back into the bathroom because of the overwhelming guilt.
Which is also why he had so much pent up aggression that was taken out on Casey, also because Casey aggravates him but he doesn’t normally ‘brawl’ with Casey and so that’s why.
After Leo wakes up, he constantly worries about his well being and not wanting to have push too hard. Even making him medicine to try and help him heal faster (we all saw how that turned out) and even greatly distressed when Leo has to face the Creep alone.
It’s also why he doesn’t argue as heavily with him, save for with Don Vizioso because of the danger his own life was put in. I feel that is also a way to try and prevent Leo from doing something alone again as well as get vengeance on the man that nearly killed him.
TL:DR; Donnie feels guilt and becomes a bit more protective over Leo’s well being.